Episode 101

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Published on:

24th Nov 2025

85:: The science of gratitude (& using gratitude to rewire your brain!)

Gratitude isn’t just a “feel-good” emotion—it’s a scientifically backed practice that can rewire your brain, balance your hormones, improve your sleep, and even strengthen your heart. In this episode, we explore the various ways to practice gratitude and how to make it a meaningful part of your daily life.

You’ll learn about three core types of gratitude:

  • Gratitude Awareness: Simple ways to journal or meditate on what you’re thankful for—because “I’m grateful for…” is more powerful than it sounds.
  • Gratitude Experience: How to feel gratitude on a deeper level by putting yourself in the shoes of others—like the inspiring story of Dick and Rick Hoyt, the father-son Ironman duo whose bond shows what gratitude in motion truly looks like.
  • Gratitude Giving: Why expressing your appreciation out loud or writing a gratitude letter can shift your mindset, boost your mood, and strengthen your relationships.

We also dive into the science of gratitude—including how it changes your brain chemistry and physiology:

  • Increased dopamine and serotonin for motivation, happiness, and emotional balance
  • Oxytocin release for deeper social connection
  • Reduced cortisol (up to 23%) and inflammation, improving both your nervous system and heart health
  • Enhanced sleep quality, HRV, and even longevity

You’ll hear about landmark studies (like Emmons & McCullough, 2003) and new 2024 research showing gratitude’s effects on cortisol, cardiovascular function, and even lifespan—especially for women.

Whether you’re journaling, meditating, or sharing your appreciation with others, this episode will help you understand why gratitude works, how to practice it effectively, and what happens to your brain and body when you do.

Tune in to learn how something as simple as saying “thank you” can reshape your health, your mindset, and your relationships.

Cortisol Series: https://player.captivate.fm/collection/fd771da6-0546-438e-aaee-24d1a9ad0fc2 

Gratitude episode from 2024: https://www.youtube.com/watch?v=YWOPSRsSVjE 

Gratitude research article:  https://pmc.ncbi.nlm.nih.gov/articles/PMC10393216/

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00:00- 00:17 Introduction

00:17- 00:59 Introduction to Gratitude and Brain Rewiring

01:00- 04:10 Types of Gratitude Practices

04:11- 04:59 The Science Behind Gratitude

05:00- 07:27 Gratitude's Impact on Inflammation and Stress

07:28- 08:26 Cardiovascular and Sleep Benefits of Gratitude

08:27- 09:08 Gender Differences in Gratitude

09:09- 10:15 Landmark Studies on Gratitude

10:16- 10:51 AD BREAK

10:51- 13:04 Gratitude's Long-Term Effects

13:05- 13:50 Best Gratitude Practices

13:51- 14:47 Conclusion and Thanksgiving Wishes

Mentioned in this episode:

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About the Podcast

Wellness Big Sis: The Pod
Wellness Big Sis: The Pod (By Maven Media) includes wellness girl chats by host, Kelsy Vick, a board-certified orthopedic Doctor of Physical Therapy. Join us as we learn about our female bodies and all aspects of wellness, creating a sisterhood of empowered wellness big sisters... without the clothes-stealing ;)
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@dr.kelsyvickdpt

About your host

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Kelsy Vick

Dr. Kelsy is a Board-Certified Orthopedic Doctor of Physical Therapy, a Pelvic Floor Physical Therapist, and the Founder of elää wellness, a global wellness education and action agency for women. As the host of wellness big sis:: the pod, she hopes to share science-backed education for young women in a fun and simplified way. Join us!

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@dr.kelsyvickdpt